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In brief : Sugar junkies

点击量:   时间:2017-09-07 06:02:01

CANCER cells have such a sweet tooth they’ll self-destruct if they can’t get their fix of sugar. A team led by Chi Dang at Johns Hopkins University in Baltimore, Maryland, were studying a gene called c-myc, which is overactive in many cancers. This allows a tumour to devour glucose. The team found that without glucose, about three-quarters of the c-myc cancer cells underwent programmed cell death. The cells also committed suicide if fed drugs that interrupt glucose metabolism (Proceedings of the National Academy of Sciences, vol 95, p 1511). The anticancer potential of such drugs was reported before, but the treatment never caught on. “Now we understand how these drugs work, it’s time to give them another chance,